CDC45-related protein
| CDC45 cell division cycle 45-like (S. cerevisiae) | |||||||||||
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| Identifiers | |||||||||||
| Symbols | CDC45L ; CDC45; CDC45L2; PORC-PI-1 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 2616 | ||||||||||
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| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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CDC45 cell division cycle 45-like (S. cerevisiae), also known as CDC45L, is a human gene.[1]
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenlyation sites of this gene are reported.[1]
References
Further reading
- Leatherwood J (1999). "Emerging mechanisms of eukaryotic DNA replication initiation". Curr. Opin. Cell Biol. 10 (6): 742–8. PMID 9914182.
- Saha P, Thome KC, Yamaguchi R; et al. (1998). "The human homolog of Saccharomyces cerevisiae CDC45". J. Biol. Chem. 273 (29): 18205–9. PMID 9660782.
- McKie JM, Wadey RB, Sutherland HF; et al. (1998). "Direct selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene". Genome Res. 8 (8): 834–41. PMID 9724329.
- Mimura S, Takisawa H (1998). "Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase Cdk". EMBO J. 17 (19): 5699–707. doi:10.1093/emboj/17.19.5699. PMID 9755170.
- Shaikh TH, Gottlieb S, Sellinger B; et al. (1999). "Characterization of CDC45L: a gene in the 22q11.2 deletion region expressed during murine and human development". Mamm. Genome. 10 (3): 322–6. PMID 10051334.
- Kukimoto I, Igaki H, Kanda T (1999). "Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha". Eur. J. Biochem. 265 (3): 936–43. PMID 10518787.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Kneissl M, Pütter V, Szalay AA, Grummt F (2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111–28. PMID 12614612.
- Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
- Ramachandran N, Hainsworth E, Bhullar B; et al. (2004). "Self-assembling protein microarrays". Science. 305 (5680): 86–90. doi:10.1126/science.1097639. PMID 15232106.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Liu P, Barkley LR, Day T; et al. (2006). "The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism". J. Biol. Chem. 281 (41): 30631–44. doi:10.1074/jbc.M602982200. PMID 16912045.
- Masai H, Taniyama C, Ogino K; et al. (2007). "Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin". J. Biol. Chem. 281 (51): 39249–61. doi:10.1074/jbc.M608935200. PMID 17046832.
- Boskovic J, Coloma J, Aparicio T; et al. (2007). "Molecular architecture of the human GINS complex". EMBO Rep. 8 (7): 678–84. doi:10.1038/sj.embor.7401002. PMID 17557111.
- Bauerschmidt C, Pollok S, Kremmer E; et al. (2007). "Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases delta and epsilon during S phase". Genes Cells. 12 (6): 745–58. doi:10.1111/j.1365-2443.2007.01090.x. PMID 17573775.
- Pollok S, Bauerschmidt C, Sänger J; et al. (2007). "Human Cdc45 is a proliferation-associated antigen". FEBS J. 274 (14): 3669–84. doi:10.1111/j.1742-4658.2007.05900.x. PMID 17608804.
- Pollok S, Grosse F (2007). "Cdc45 degradation during differentiation and apoptosis". Biochem. Biophys. Res. Commun. 362 (4): 910–5. doi:10.1016/j.bbrc.2007.08.069. PMID 17767920.
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