Indospicine

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

WikiDoc Resources for Indospicine
Articles
Most recent articles on Indospicine Most cited articles on Indospicine Review articles on Indospicine Articles on Indospicine in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Indospicine Images of Indospicine Photos of Indospicine Podcasts & MP3s on Indospicine Videos on Indospicine
Evidence Based Medicine
Cochrane Collaboration on Indospicine Bandolier on Indospicine TRIP on Indospicine
Clinical Trials
Ongoing Trials on Indospicine at Clinical Trials.gov Trial results on Indospicine Clinical Trials on Indospicine at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Indospicine NICE Guidance on Indospicine NHS PRODIGY Guidance FDA on Indospicine CDC on Indospicine
Books
Books on Indospicine
News
Indospicine in the news Be alerted to news on Indospicine News trends on Indospicine
Commentary
Blogs on Indospicine
Definitions
Definitions of Indospicine
Patient Resources / Community
Patient resources on Indospicine Discussion groups on Indospicine Patient Handouts on Indospicine Directions to Hospitals Treating Indospicine Risk calculators and risk factors for Indospicine
Healthcare Provider Resources
Symptoms of Indospicine Causes & Risk Factors for Indospicine Diagnostic studies for Indospicine Treatment of Indospicine
Continuing Medical Education (CME)
CME Programs on Indospicine
International
Indospicine en Espanol Indospicine en Francais
Business
Indospicine in the Marketplace Patents on Indospicine
Experimental / Informatics
List of terms related to Indospicine

Overview

L-Indospicin [synonym: (S)-Indospicin] is a toxic , non- proteinogenic amino acid from the legume Indigofera endecaphylla . There it comes in amounts of up to 0.15% in the herb and up to 2.0% in the seeds before.

This plant is used as a forage crop in tropical areas. The offspring of pregnant animals, which eat the plant suffered a embryopathisches syndrome characterized by cleft palate , dwarfism , and acute liver damage is characterized. Furthermore, even were liver cirrhosis was observed. In humans, but so far no known poisonings.

The toxic effects (eg it is made ​​responsible for certain equine diseases) based on the action as L - arginine - an antimetabolite and a consequent impairment of protein biosynthesis. It also inhibits the constitutive and inducible NO synthase and is teratogenic .

L-Indospicin also occurs in other species such as Indigofera Indigofera mucronata and is suspected in several others. Because in addition to these poisons Indospicin the canavanine and Hiptagensäure are, there is some conflicting evidence in the literature about the nature and severity of the toxicity of the plant.

References

Template:WH Template:WS