Bicuspid aortic stenosis pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

A congenital bicuspid aortic valve may be associated with the development of either progressive clacific stenosis or regurgitation. The defect is the leading cause of acquired calcified aortic stenosis.

Incidence of Concommittant Valve Disease

• Only 25% of patients with congenital aortic stenosis (AS) have aortic insufficiency (AI) compared with 75% of cases with acquired AS.
• In 75% of those with acquired AS, there is associated mitral valve disease. This association is rare in congenital AS.