Hepatitis E pathophysiology

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Hepatitis E virus
TEM micrograph of hepatitis E virions.
TEM micrograph of hepatitis E virions.
Virus classification
Group: Group IV ((+)ssRNA)
Family: Hepeviridae
Genus: Hepevirus
Species: Hepatitis E virus

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Virology

The viral particles are 27 to 34 nanometers in diameter, are non-enveloped and contain a single-strand of positive-sense RNA that is approximately 7300 bases in length. The virus particle was first visualised in 1983[1] but was only molecularly cloned in 1990.[2]

It was previously classified family Caliciviridae. However, its genome more closely resembles the rubella virus. It is now classified in a new virus family, named as Hepeviridae.

References

  1. Balayan MS, Andjaparidze AG, Savinskaya SS; et al. (1983). "Evidence for a virus in non-A, non-B hepatitis transmitted via the fecal-oral route". Intervirology. 20 (1): 23–31. PMID 6409836.
  2. Reyes GR, Purdy MA, Kim JP; et al. (1990). "Isolation of a cDNA from the virus responsible for enterically transmitted non-A, non-B hepatitis". Science. 247 (4948): 1335–9. doi:10.1126/science.2107574. PMID 2107574.

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