Sandbox:Ifeoma Anaya
Synonyms and keywords: Exanthema subitum; sixth disease; roseola infantilis
Roseola Infantum
Overview
Historical Perspective
Previously known as "Roseola infantilis", the oldest known description of the disease dates as far back as 100 years ago by John Zahorsky, M.D in his publication in 1913 [1] [2]. Described as a symptom-complex of febrille erythema occuring in infants and not to be categorized alongside the erythema group of skin diseases. However, no clear-cut description was given to differentiate it from other pediatric skin eruptions. The name was subsequently dropped [1] .
Pathophysiology
Causes
Disease is caused by the Human Herpes Virus type 6, HHV-6 and less commonly by HHV-7. The HHV-6 has its primary variant, HHV-6A which is the associated with Roseola infantum while the other variant, HHV-6A has not been associated with any disease(s) [3].
Epidemiology and Demographics
Children are the most commonly infected and more severe disease pathology can be seen in the immunocompromised because it remains latent in the body after primary infection [4] [5].
Natural History, Complications and Prognosis
Diagnosis
Treatment
Prevention
Differentiating Roseola Infantum from other Diseases
| classification | ||||
|---|---|---|---|---|
| SCC | ||||
| BCC | ||||
| Melanoma | ||||
Practice here
| Criteria | Symptomatic WM | Asymptomatic WM | IgM-Related Disorders | MGUS |
|---|---|---|---|---|
| IgM monoclonal protein | + | + | + | + |
| Bone marrow infiltration | + | + | - | - |
| Symptoms attributable to IgM | + | - | + | - |
| Symptoms attributable to tumor infiltration | + | - | - | - |
|
Bowen's disease Microchapters |
References
- ↑ 1.0 1.1 Zahorsky, John (1913). "ROSEOLA INFANTUM". JAMA: The Journal of the American Medical Association. 61 (16): 1446. doi:10.1001/jama.1913.04350170028008. ISSN 0098-7484.
- ↑ Altschuler, Eric Lewin (2000). "OLDEST DESCRIPTION OF ROSEOLA AND IMPLICATIONS FOR THE ANTIQUITY OF HUMAN HERPESVIRUS 6". The Pediatric Infectious Disease Journal. 19 (9): 903. doi:10.1097/00006454-200009000-00025. ISSN 0891-3668.
- ↑ "StatPearls". 2020. PMID 28846307.
- ↑ Bates M, Monze M, Bima H, Kapambwe M, Clark D, Kasolo FC; et al. (2009). "Predominant human herpesvirus 6 variant A infant infections in an HIV-1 endemic region of Sub-Saharan Africa". J Med Virol. 81 (5): 779–89. doi:10.1002/jmv.21455. PMID 19319952.
- ↑ Yoshikawa T (2001). "Human herpesvirus 6 infection in transplantation". Nagoya J Med Sci. 64 (1–2): 11–8. PMID 11486597.