Cryopyrin-associated periodic syndrome MRI

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]

Overview

There are no MRI findings associated with the cryopyrin-associated periodic syndrome. However, an MRI may be helpful in the diagnosis of arthropathy associated with neonatal-onset multisystem inflammatory disease (NOMID) which includes enlarged, heterogenous physis with hypointense calcifications and presence of popliteal lymph node.

MRI

  • There are no MRI findings associated with the cryopyrin-associated periodic syndrome. However, an MRI may be helpful in the diagnosis of arthropathy associated with neonatal-onset multisystem inflammatory disease (NOMID).[1]
  • Findings associated with arthropathy of NOMID include:
    • Presence of popliteal lymph node is another recognized feature
    • Absence of bony erosion
    • T1 and T2 images: Enlarged, heterogenous physis with hypointense calcifications
    • Post-gadolinium images show heterogenous enhancement at the physis

References

  1. Sridharan, Radhika; Mohd Zaki, Faizah; Sook Pei, Tan; Swee Ping, Tang; Ibrahim, Sharaf (2012). "NOMID: The radiographic and MRI features and review of literature". Journal of Radiology Case Reports. 6 (3). doi:10.3941/jrcr.v6i3.745. ISSN 1943-0922.

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