Paget's disease of the breast history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]

Overview

Symptoms of Paget's disease of the breast include itching, redness, thickened skin, and ulceration of the nipple.

History and symptoms

History

A detailed history documenting the length of time the lesion along with any associated symptoms should be taken.By clinical history, the cancer risk can be evaluated:[1]

Symptoms

Symptoms of Paget's disease of the breast usually occur in one breast but can present bilaterally. Some patients have two or more or a combination of the below symptoms at presentation. They can also be asymptomatic. Symptoms of Paget's disease of the breast include: [2][3][4][5][6]

  • Pruritis or erythema of the nipple and/or areola.
  • Flaking, crusting, or thickening of the skin that begins at the nipple and spreads to the areola with irregular borders.
  • Erosion or ulceration of the nipple.
  • A flattened, inverted or retracted nipple.
  • Bloody or serosanguinous discharge from the nipple.
  • A palpable breast mass is present in 50% of patients.

References

  1. Shah R, Rosso K, Nathanson SD (2014). "Pathogenesis, prevention, diagnosis and treatment of breast cancer". World J Clin Oncol. 5 (3): 283–98. doi:10.5306/wjco.v5.i3.283. PMC 4127601. PMID 25114845.
  2. Chen CY, Sun LM, Anderson BO (October 2006). "Paget disease of the breast: changing patterns of incidence, clinical presentation, and treatment in the U.S". Cancer. 107 (7): 1448–58. doi:10.1002/cncr.22137. PMID 16933329.
  3. Kanitakis J (May 2007). "Mammary and extramammary Paget's disease". J Eur Acad Dermatol Venereol. 21 (5): 581–90. doi:10.1111/j.1468-3083.2007.02154.x. PMID 17447970.
  4. Ashikari R, Park K, Huvos AG, Urban JA (September 1970). "Paget's disease of the breast". Cancer. 26 (3): 680–5. PMID 4318756.
  5. Tan AR (June 2016). "Cutaneous manifestations of breast cancer". Semin. Oncol. 43 (3): 331–4. doi:10.1053/j.seminoncol.2016.02.030. PMID 27178684.
  6. Franceschini G, Masetti R, D'Ugo D, Palumbo F, D'Alba P, Mulè A, Costantini M, Belli P, Picciocchi A (2005). "Synchronous bilateral Paget's disease of the nipple associated with bilateral breast carcinoma". Breast J. 11 (5): 355–6. doi:10.1111/j.1075-122X.2005.21722.x. PMID 16174159.


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