EMCN

Revision as of 18:53, 21 August 2018 by en>OAbot (Open access bot: add pmc identifier to citation with #oabot.)
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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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View/Edit Human

Endomucin is a protein that in humans is encoded by the EMCN gene.[1][2][3] Endomucin is a marker for endothelial cells[4] and hematopoietic stem cells.[5]

Function

EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.[1][3]

References

  1. 1.0 1.1 Kinoshita M, Nakamura T, Ihara M, Haraguchi T, Hiraoka Y, Tashiro K, Noda M (June 2001). "Identification of human endomucin-1 and -2 as membrane-bound O-sialoglycoproteins with anti-adhesive activity". FEBS Letters. 499 (1–2): 121–6. doi:10.1016/S0014-5793(01)02520-0. PMID 11418125.
  2. Liu C, Shao ZM, Zhang L, Beatty P, Sartippour M, Lane T, Livingston E, Nguyen M (October 2001). "Human endomucin is an endothelial marker". Biochemical and Biophysical Research Communications. 288 (1): 129–36. doi:10.1006/bbrc.2001.5737. PMID 11594763.
  3. 3.0 3.1 "Entrez Gene: EMCN endomucin".
  4. 1.Liu, C. et al. Human Endomucin Is an Endothelial Marker. Biochemical and Biophysical Research Communications 288, 129-136 (2001).
  5. Matsubara A.; et al. (2005). "Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development". Journal of Experimental Medicine. 11 (202): 1483. doi:10.1084/jem.20051325. PMC 2213340.

Further reading