Parkinson's disease MRI
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
MRI
- Diagnosis of Parkinson disease is mostly clinical but there are some MRI finding supporting the diagnosis.
- In the STN of PD patients there are increased amount of iron. The excess iron will cause a reduction in T2 relaxation time and it’s more prominent in one side.[1] There are also evidence of reduced iron content in putamen and GPe.[2][3]
- We can also use MRI to differentiate PD from other conditions. for example in the midbrain, thinning of anteroposterior diameter and enlargement of third ventricle in suggestive of supranuclear palsy.[4][5]
- Also we can see atrophy of brainstem and cerebellum in multiple system atrophy.[6][7]
References
- ↑ Kosta P, Argyropoulou MI, Markoula S, Konitsiotis S (January 2006). "MRI evaluation of the basal ganglia size and iron content in patients with Parkinson's disease". J. Neurol. 253 (1): 26–32. doi:10.1007/s00415-005-0914-9. PMID 15981079.
- ↑ Graham JM, Paley MN, Grünewald RA, Hoggard N, Griffiths PD (December 2000). "Brain iron deposition in Parkinson's disease imaged using the PRIME magnetic resonance sequence". Brain. 123 Pt 12: 2423–31. PMID 11099445.
- ↑ Ryvlin P, Broussolle E, Piollet H, Viallet F, Khalfallah Y, Chazot G (June 1995). "Magnetic resonance imaging evidence of decreased putamenal iron content in idiopathic Parkinson's disease". Arch. Neurol. 52 (6): 583–8. PMID 7763206.
- ↑ Stern MB, Braffman BH, Skolnick BE, Hurtig HI, Grossman RI (November 1989). "Magnetic resonance imaging in Parkinson's disease and parkinsonian syndromes". Neurology. 39 (11): 1524–6. PMID 2812334.
- ↑ Asato R, Akiguchi I, Masunaga S, Hashimoto N (2000). "Magnetic resonance imaging distinguishes progressive supranuclear palsy from multiple system atrophy". J Neural Transm (Vienna). 107 (12): 1427–36. doi:10.1007/s007020070006. PMID 11458995.
- ↑ Konagaya M, Konagaya Y, Iida M (December 1994). "Clinical and magnetic resonance imaging study of extrapyramidal symptoms in multiple system atrophy". J. Neurol. Neurosurg. Psychiatry. 57 (12): 1528–31. PMC 1073237. PMID 7798985.
- ↑ Yekhlef F, Ballan G, Macia F, Delmer O, Sourgen C, Tison F (February 2003). "Routine MRI for the differential diagnosis of Parkinson's disease, MSA, PSP, and CBD". J Neural Transm (Vienna). 110 (2): 151–69. doi:10.1007/s00702-002-0785-5. PMID 12589575.