Paroxysmal nocturnal hemoglobinuria history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
History and Symptoms
History
Patients with PNH may have a positive history of:
- Feeling tired/ weak
- Shortness of breath
- Dark colored urine
- Jaundice
- Blood clots
- Difficulty swallowing
- Chest pain
- Abdominal pain
- Headaches
- Confusion
- Dysphagia
- Erectile dysfunction
- Low blood cell counts
- Iron deficiency
Common Symptoms
Common symptoms of PNH include:
- Due to hemolysis
- Fatigue
- Dyspnea
- Jaundice
- Due to thrombosis:
- Headaches
- Confusion
- Abdominal pain
- Chest pain
- Due to nitric oxide depletion:
- Dysphagia
- Chest pain
- Abdominal pain
- Erectile dysfunction
Less Common Symptoms
Less common symptoms of PNH include: