Von Willebrand disease history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nazia Fuad M.D.

Overview

Patients with von Willebrand’s disease present with history of mucosal bleeding, recurrent nose bleeds, oral cavity bleeding, and positive family history of similer symptoms among other family members. Adults patients with vWD mainly present with bleeding after dental extraction/ or other surgery. Heavy menstrual periods and postpartum hemorrhage are common among affected females with von Willebrand’s disease. Severe internal or joint bleeding can occur but is usually rare.

Symptoms

History

Patients with von Willebrand’s disease may have a positive history of:[1]

  • Personal bleeding
  • Family history of bleeding
  • Bruising without obvious trauma
  • Recurrent nose bleeds
  • Oral cavity bleeding
  • Bleeding from the gums after brushing or flossing teeth
  • Prolonged bleeding following dental cleaning or extractions.

Common Symptoms

Common symptoms of von Willebrand’s disease include:[2]

Less Common Symptoms

Less common symptoms of von Willebrand’s disease include[3]

References

  1. Nichols WL, Hultin MB, James AH, Manco-Johnson MJ, Montgomery RR, Ortel TL; et al. (2008). "von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA)". Haemophilia. 14 (2): 171–232. doi:10.1111/j.1365-2516.2007.01643.x. PMID 18315614.
  2. Keesler DA, Flood VH (January 2018). "Current issues in diagnosis and treatment of von Willebrand disease". Res Pract Thromb Haemost. 2 (1): 34–41. doi:10.1002/rth2.12064. PMC 5974913. PMID 30046704.
  3. Leebeek F, Susen S (May 2018). "Von Willebrand disease: Clinical conundrums". Haemophilia. 24 Suppl 6: 37–43. doi:10.1111/hae.13508. PMID 29878657. Vancouver style error: initials (help)

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