Von Willebrand disease history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Prince Tano Djan, BSc, MBChB [2]

Overview

Adults patients with vWD mainly present with bleeding after surgery (example bleeding after dental extraction/surgery), mucosa-associated bleeding, Heavy menstrual periods and postpartum hemorrhage. Severe internal or joint bleeding is rare.

Symptoms

History

Patients with von Willebrand’s disease may have a positive history of:[1]

  • Bleeding
  • Family history of bleeding
  • Bruising without obvious trauma
  • Recurrent nose bleeds
  • Oral cavity bleeding
  • Bleeding from the gums after brushing or flossing teeth
  • Prolonged bleeding following dental cleaning or extractions.

Common Symptoms

Common symptoms of von Willebrand’s disease include:

Less Common Symptoms

Less common symptoms of von Willebrand’s disease include

References

  1. Nichols WL, Hultin MB, James AH, Manco-Johnson MJ, Montgomery RR, Ortel TL; et al. (2008). "von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA)". Haemophilia. 14 (2): 171–232. doi:10.1111/j.1365-2516.2007.01643.x. PMID 18315614.

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