Palmar Plantar Erythrodysesthesia​

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords:Palmar plantar erythrodysesthesia, Palmar-Plantar Erythrodysesthesia; Palmoplantar Erythrodysesthesia; Hand-Foot Syndrome

Overview

Palmar Plantar Erythrodystesia or Hand-Foot syndrome is a skin-related reaction to chemotherapy and other drugs used to treat patients with cancer.

Historical Perspective

Classification

Pathophysiology

Genetics

Associated Conditions

Gross Pathology

Microscopic Pathology

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Common Causes

Causes by Organ System

Less Common Causes

  • Docetaxel [1]
  • Capacitabine-based chemotherapy[2]
Cardiovascular No underlying causes
Chemical / poisoning No underlying causes
Dermatologic No underlying causes
Drug Side Effect No underlying causes
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic No underlying causes
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal / Ortho No underlying causes
Neurologic No underlying causes
Nutritional / Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic No underlying causes
Opthalmologic No underlying causes
Overdose / Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal / Electrolyte No underlying causes
Rheum / Immune / Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Dental No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order

  • A...
  • Z...

Make sure that each diagnosis is linked to a page.

Differentiating type page name here from other Diseases

Epidemiology and Demographics

Age

Gender

Race

Developed Countries

Developing Countries

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria

If available, the diagnostic criteria are provided here.

History

A directed history should be obtained to ascertain

Symptoms

"Type symptom here" is pathognomonic of the "type disease name here".

"Type non specific symptoms" may be present.

Past Medical History

Family History

Social History

Occupational

Alcohol

The frequency and amount of alcohol consumption should be characterized.

Drug Use

Smoking

Allergies

Physical Examination

Appearance of the Patient

Vital Signs

Skin

Head

Eyes

Ear

Nose

Mouth

Throat

Heart

Lungs

Abdomen

Extremities

Neurologic

Genitals

Other

Laboratory Findings

Electrolyte and Biomarker Studies

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Pharmacotherapy

Acute Pharmacotherapies

Chronic Pharmacotherapies

Surgery and Device Based Therapy

Indications for Surgery

Pre-Operative Assessment

Post-Operative Management

Transplantation

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

References

WikiDoc Resources for Palmar Plantar Erythrodysesthesia​

Articles

Most recent articles on Palmar Plantar Erythrodysesthesia​

Most cited articles on Palmar Plantar Erythrodysesthesia​

Review articles on Palmar Plantar Erythrodysesthesia​

Articles on Palmar Plantar Erythrodysesthesia​ in N Eng J Med, Lancet, BMJ

Media

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Evidence Based Medicine

Cochrane Collaboration on Palmar Plantar Erythrodysesthesia​

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TRIP on Palmar Plantar Erythrodysesthesia​

Clinical Trials

Ongoing Trials on Palmar Plantar Erythrodysesthesia​ at Clinical Trials.gov

Trial results on Palmar Plantar Erythrodysesthesia​

Clinical Trials on Palmar Plantar Erythrodysesthesia​ at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Palmar Plantar Erythrodysesthesia​

NICE Guidance on Palmar Plantar Erythrodysesthesia​

NHS PRODIGY Guidance

FDA on Palmar Plantar Erythrodysesthesia​

CDC on Palmar Plantar Erythrodysesthesia​

Books

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News

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Commentary

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Definitions

Definitions of Palmar Plantar Erythrodysesthesia​

Patient Resources / Community

Patient resources on Palmar Plantar Erythrodysesthesia​

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Directions to Hospitals Treating Palmar Plantar Erythrodysesthesia​

Risk calculators and risk factors for Palmar Plantar Erythrodysesthesia​

Healthcare Provider Resources

Symptoms of Palmar Plantar Erythrodysesthesia​

Causes & Risk Factors for Palmar Plantar Erythrodysesthesia​

Diagnostic studies for Palmar Plantar Erythrodysesthesia​

Treatment of Palmar Plantar Erythrodysesthesia​

Continuing Medical Education (CME)

CME Programs on Palmar Plantar Erythrodysesthesia​

International

Palmar Plantar Erythrodysesthesia​ en Espanol

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Business

Palmar Plantar Erythrodysesthesia​ in the Marketplace

Patents on Palmar Plantar Erythrodysesthesia​

Experimental / Informatics

List of terms related to Palmar Plantar Erythrodysesthesia​

  1. Harris CS, Wang D, Carulli A (2014). "Docetaxel-associated palmar-plantar erythrodysesthesia: a case report and review of the literature". J Oncol Pharm Pract. 20 (1): 73–80. doi:10.1177/1078155213475466. PMID 23478198.
  2. Krikorian A, Rahmani R, Bromet M, Bore P, Cano JP (1989). "Pharmacokinetics and metabolism of Navelbine". Semin Oncol. 16 (2 Suppl 4): 21–5. PMID 2652317.