Methemoglobinemia medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Template:Aksiniya K. Stevasarova, M.D.

Overview

Methemoglobinemia should be promptly treated once diagnosed.

Medical Therapy

  • Initial management of methemoglobinemia patients includes administration of supplemental oxygen and if the toxin is still present on the skin, the clothes should be promptly removed and the skin washed. If the patient cannot provide information on the cause of the presenting symptoms, we could check the blood levels of MetHb and also perform gastric lavage. In asymptomatic patients, we can measure the serum levels of MetHb multiple times until the levels normalize, which usually happens.[1] [2]

References

  1. do Nascimento TS, Pereira RO, de Mello HL, Costa J (2008). "Methemoglobinemia: from diagnosis to treatment". Rev Bras Anestesiol. 58 (6): 651–64. PMID 19082413.
  2. Skold A, Cosco DL, Klein R (2011). "Methemoglobinemia: pathogenesis, diagnosis, and management". South Med J. 104 (11): 757–61. doi:10.1097/SMJ.0b013e318232139f. PMID 22024786.
  3. Ashurst J, Wasson M (2011). "Methemoglobinemia: a systematic review of the pathophysiology, detection, and treatment". Del Med J. 83 (7): 203–8. PMID 21954509.
  4. Rehman A, Shehadeh M, Khirfan D, Jones A (2018). "Severe acute haemolytic anaemia associated with severe methaemoglobinaemia in a G6PD-deficient man". BMJ Case Rep. 2018. doi:10.1136/bcr-2017-223369. PMID 29592989.
  5. Bradberry SM (2003). "Occupational methaemoglobinaemia. Mechanisms of production, features, diagnosis and management including the use of methylene blue". Toxicol Rev. 22 (1): 13–27. PMID 14579544.

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