Major or mild neurocognitive disorder due to Parkinson's disease

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]

Overview

Major or Mild Neurocognitive Disorder Due to Parkinson's Disease

Epidemiology and Demographics

Prevalence

The prevalence of major or mild neurocognitive disorder due to parkinson's disease is:

75,000 per 100,000 (75%) major neurocognitive disorder.

27,000 per 100,000 (27%) mild neurocognitive disorder.[1]

Risk Factors

Risk factors for developing Cognitive impairment and dementia in Parkinson disease are: Duration of PD, severity of the disease, age of onset >60 years, old age, presence of rapid eye movement sleep behavior disorder, autonomic dysfunction, gait problem and hyposmia.[2][3][4][5][6][7][8][9][10]

Differential Diagnosis

the differential diagnosis for PDD includes:

  • Dementia with Lewy bodies
  • Multiple system atrophy
  • Corticobasal degeneration
  • Progressive supranuclear palsy.
  • vascular parkinsonism

References

  1. Diagnostic and statistical manual of mental disorders : DSM-5. Washington, D.C: American Psychiatric Association. 2013. ISBN 0890425558.
  2. Anang JB, Gagnon JF, Bertrand JA, Romenets SR, Latreille V, Panisset M, Montplaisir J, Postuma RB (September 2014). "Predictors of dementia in Parkinson disease: a prospective cohort study". Neurology. 83 (14): 1253–60. doi:10.1212/WNL.0000000000000842. PMC 4180482. PMID 25171928.
  3. Schrag A, Siddiqui UF, Anastasiou Z, Weintraub D, Schott JM (January 2017). "Clinical variables and biomarkers in prediction of cognitive impairment in patients with newly diagnosed Parkinson's disease: a cohort study". Lancet Neurol. 16 (1): 66–75. doi:10.1016/S1474-4422(16)30328-3. PMC 5377592. PMID 27866858.
  4. Hughes TA, Ross HF, Musa S, Bhattacherjee S, Nathan RN, Mindham RH, Spokes EG (April 2000). "A 10-year study of the incidence of and factors predicting dementia in Parkinson's disease". Neurology. 54 (8): 1596–602. PMID 10762499.
  5. Reid WG, Hely MA, Morris JG, Broe GA, Adena M, Sullivan DJ, Williamson PM (October 1996). "A longitudinal of Parkinson's disease: clinical and neuropsychological correlates of dementia". J Clin Neurosci. 3 (4): 327–33. PMID 18638897.
  6. Stern Y, Marder K, Tang MX, Mayeux R (September 1993). "Antecedent clinical features associated with dementia in Parkinson's disease". Neurology. 43 (9): 1690–2. PMID 8414013.
  7. Mayeux R, Denaro J, Hemenegildo N, Marder K, Tang MX, Cote LJ, Stern Y (May 1992). "A population-based investigation of Parkinson's disease with and without dementia. Relationship to age and gender". Arch. Neurol. 49 (5): 492–7. PMID 1580811.
  8. Hobson P, Meara J (September 2004). "Risk and incidence of dementia in a cohort of older subjects with Parkinson's disease in the United Kingdom". Mov. Disord. 19 (9): 1043–9. doi:10.1002/mds.20216. PMID 15372593.
  9. Aarsland D, Andersen K, Larsen JP, Lolk A, Nielsen H, Kragh-Sørensen P (March 2001). "Risk of dementia in Parkinson's disease: a community-based, prospective study". Neurology. 56 (6): 730–6. PMID 11274306.
  10. Aarsland D, Andersen K, Larsen JP, Lolk A, Kragh-Sørensen P (March 2003). "Prevalence and characteristics of dementia in Parkinson disease: an 8-year prospective study". Arch. Neurol. 60 (3): 387–92. PMID 12633150.