Variable charge X-linked protein 1 is a protein that in humans is encoded by the VCXgene.[1][2][3]
This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit.[3]
References
↑Lahn BT, Page DC (Feb 2000). "A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins". Hum Mol Genet. 9 (2): 311–9. doi:10.1093/hmg/9.2.311. PMID10607842.
Zou SW, Zhang JC, Zhang XD, et al. (2004). "Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis". Cell Res. 13 (3): 171–7. doi:10.1038/sj.cr.7290161. PMID12862317.
Sy SM, Wong N, Mok TS, et al. (2003). "Genetic alterations of lung adenocarcinoma in relation to smoking and ethnicity". Lung Cancer. 41 (1): 91–9. doi:10.1016/S0169-5002(03)00138-7. PMID12826317.
