Metalloreductase STEAP2 is an enzyme that in humans is encoded by the STEAP2gene.[1][2][3]
This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[3]
↑Korkmaz KS, Elbi C, Korkmaz CG, Loda M, Hager GL, Saatcioglu F (Sep 2002). "Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer". J Biol Chem. 277 (39): 36689–96. doi:10.1074/jbc.M202414200. PMID12095985.
Korkmaz CG, Korkmaz KS, Kurys P, et al. (2005). "Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer". Oncogene. 24 (31): 4934–45. doi:10.1038/sj.onc.1208677. PMID15897894.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Porkka KP, Helenius MA, Visakorpi T (2002). "Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate". Lab. Invest. 82 (11): 1573–82. doi:10.1097/01.lab.0000038554.26102.c6. PMID12429817.
