The human ARG1 gene encodes the protein arginase .
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Function Arginase catalyzes the hydrolysis of arginine to ornithine and urea . At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle . Inherited deficiency of this enzyme results in argininemia , an autosomal recessive disorder characterized by hyperammonemia . Two transcript variants encoding different isoforms have been found for this gene.[2]
References External links Further reading
Morris, C. R.; Kato, G. J.; Poljakovic, M.; Wang, X.; Blackwelder, W. C.; Sachdev, V.; Hazen, S. L.; Vichinsky, E. P.; Morris Jr, S. M.; Gladwin, M. T. (2005). "Dysregulated Arginine Metabolism, Hemolysis-Associated Pulmonary Hypertension, and Mortality in Sickle Cell Disease" . JAMA . 294 (1): 81–90. doi :10.1001/jama.294.1.81 . PMC 2065861 PMID 15998894 . Jiang, M.; Ding, Y.; Su, Y.; Hu, X.; Li, J.; Zhang, Z. (2006). "Arginase-flotillin interaction brings arginase to red blood cell membrane". FEBS Letters . 580 (28–29): 6561–6564. doi :10.1016/j.febslet.2006.11.003 . PMID 17113085 . Morris Jr, S. M. (2009). "Recent advances in arginine metabolism: Roles and regulation of the arginases" . British Journal of Pharmacology . 157 (6): 922–930. doi :10.1111/j.1476-5381.2009.00278.x . PMC 2737650 PMID 19508396 . Rotondo, R.; Bertolotto, M.; Barisione, G.; Astigiano, S.; Mandruzzato, S.; Ottonello, L.; Dallegri, F.; Bronte, V.; Ferrini, S.; Barbieri, O. (2011). "Exocytosis of azurophil and arginase 1-containing granules by activated polymorphonuclear neutrophils is required to inhibit T lymphocyte proliferation". Journal of Leukocyte Biology . 89 (5): 721–727. doi :10.1189/jlb.1109737 . PMID 21330347 . Shapiro, M. B.; Senapathy, P. (1987). "RNA splice junctions of different classes of eukaryotes: Sequence statistics and functional implications in gene expression" . Nucleic Acids Research . 15 (17): 7155–7174. doi :10.1093/nar/15.17.7155 . PMC 306199 PMID 3658675 . Rotondo, R.; Barisione, G.; Mastracci, L.; Grossi, F.; Orengo, A. M.; Costa, R.; Truini, M.; Fabbi, M.; Ferrini, S.; Barbieri, O. (2009). "IL-8 induces exocytosis of arginase 1 by neutrophil polymorphonuclears in nonsmall cell lung cancer". International Journal of Cancer . 125 (4): 887–893. doi :10.1002/ijc.24448 . PMID 19431148 . Salam, M. T.; Bastain, T. M.; Rappaport, E. B.; Islam, T.; Berhane, K.; Gauderman, W. J.; Gilliland, F. D. (2011). "Genetic variations in nitric oxide synthase and arginase influence exhaled nitric oxide levels in children" . Allergy . 66 (3): 412–419. doi :10.1111/j.1398-9995.2010.02492.x . PMC 3058253 PMID 21039601 . Gannon, P. O.; Godin-Ethier, J.; Hassler, M.; Delvoye, N.; Aversa, M.; Poisson, A. O.; Péant, B.; Alam Fahmy, M.; Saad, F.; Lapointe, R. J.; Mes-Masson, A. M. (2010). Creighton, Chad, ed. "Androgen-Regulated Expression of Arginase 1, Arginase 2 and Interleukin-8 in Human Prostate Cancer" . PLoS ONE . 5 (8): e12107. doi :10.1371/journal.pone.0012107 . PMC 2920336 PMID 20711410 . Ishikawa, T.; Harada, T.; Koi, H.; Kubota, T.; Azuma, H.; Aso, T. (2007). "Identification of Arginase in Human Placental Villi". Placenta . 28 (2–3): 133–138. doi :10.1016/j.placenta.2006.03.015 . PMID 16720041 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
