Copine-6 is a protein that in humans is encoded by the CPNE6gene.[1][2]
This gene encodes a brain-specific member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains, and one von Willebrand factor A domain. It may have a role in synaptic plasticity.[2]
References
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Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Nakayama T, Yaoi T, Kuwajima G (1999). "Localization and subcellular distribution of N-copine in mouse brain". J. Neurochem. 72 (1): 373–9. doi:10.1046/j.1471-4159.1999.0720373.x. PMID9886090.
Nakayama T, Yaoi T, Kuwajima G, et al. (1999). "Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma". FEBS Lett. 453 (1–2): 77–80. doi:10.1016/S0014-5793(99)00700-0. PMID10403379.
Caudell EG, Caudell JJ, Tang CH, et al. (2000). "Characterization of human copine III as a phosphoprotein with associated kinase activity". Biochemistry. 39 (42): 13034–43. doi:10.1021/bi001250v. PMID11041869.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.