Chronic pancreatitis pathophysiology
| https://https://www.youtube.com/watch?v=met9SntRZe8%7C350}} |
|
Chronic pancreatitis Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
American Pancreatic Association Practice Guidelines |
|
Chronic pancreatitis pathophysiology On the Web |
|
American Roentgen Ray Society Images of Chronic pancreatitis pathophysiology |
|
Risk calculators and risk factors for Chronic pancreatitis pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Please help WikiDoc by adding content here. It's easy! Click here to learn about editing.
Overview
Pathophysiology
- Chronic pancreatitis is a progressive inflammatory process leading to irreversible structural damage to pancreas resulting in exocrine and endocrine dysfunction[1]
- The pathogenesis is still unclear but two findings consistently seen in the pathogenesis of chronic pancreatitis are:
- Protein hypersecretion resulting in proteinaceous ductal plugs leading to ductal blockage and obstruction[2]
- Patchy inflammatory lesions in exocrine pancreas seen on microscopic examination
Following factors are thought to play an important role in the pathogenesis of chronic pancreatitis:
(a) Intraductal plugging and obstruction
(b) Direct injury to pancreatic cells induced by toxins and toxic metabolites
(c) Antioxidants
(d) Ischemia
(e) Autoimmune disorders
(f) Necrosis and fibrosis
Genetics
Genes involved in the pathogenesis of chronic pancreatitis include:
- Cystic fibrosis gene mutation
- Pancreatitis susceptibility genes
Associated Conditions
Gross Pathology
- Patchy focal disease
- Fibrosis
Microscopic Pathology
- On microscopic histopathological analysis:
- Patchy focal disease characterized by a mononuclear infiltrate
- Fibrosis
References
- ↑ Steer ML, Waxman I, Freedman S (1995). "Chronic pancreatitis". N. Engl. J. Med. 332 (22): 1482–90. doi:10.1056/NEJM199506013322206. PMID 7739686.
- ↑ Sahel J, Sarles H (1979). "Modifications of pure human pancreatic juice induced by chronic alcohol consumption". Dig. Dis. Sci. 24 (12): 897–905. PMID 510088.