Osteoporosis historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Eiman Ghaffarpasand, M.D. [2]

Overview

Osteoporosis was first discovered by John Hunter, a British surgeon, in 1800's and he was also the first one to introduce the process of remodeling. Jean Lobstein, a French pathologist during 1830's, found that there are normal holes in every bone but bones in people with specific age and diseases, have holes of larger than normal size. He named this kind of bones as porous, and the disease was named as osteoporosis.

Historical perspective

The historical perspective of osteoporosis has been given below:

 
 
 
Initial identification of bone resorption
Dowager's hump seen in Egyptian mummies
4000 years ago
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Osteoporosis discovered
by: John Hunter, a British surgeon
in: 1800's
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Osteoporosis name coined
by: Jean Lobstein, a French pathologist
in: 1830's
 
 
 
Age-related bone loss defined
by: Astley Cooper, an English surgeon
in: 1830's
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Postmenopausal bone loss defined
&
Postmenopausal osteoporosis treated with estrogen
by: Fuller Albright, an American endocrinologist
in: 1940's
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bone densitometers developed
by: Norman, an American researcher
in: 1950
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Bisphosphonates discovered
by: Herbert Fleisch, a physiologist from Switzerland
in: 1960's
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Osteoporosis publicized
by: National Institute of Health (NIH)
in: 1984
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Specific cytokines that influence osteoclasts activity discovered
in: 1990's
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
T-score used to classify and define bone mineral density (BMD)
by: world health organization (WHO)
in: 1994
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Selective estrogen receptor modulators (SERMs) introduced in market
in: 1998
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Expert panel for prevention, diagnosis, and treatment of osteoporosis assembled
by: National Institute of Health (NIH)
in: 2000
 
 
 


References

  1. "History of Osteoporosis".
  2. Lobstein JGCFM. Lehrbuch der pathologischen Anatomie. Stuttgart: Bd II, 1835.
  3. Albright F, Bloomberg E, Smith PH (1940). "Postmenopausal osteoporosis". Trans. Assoc. Am. Physicians. 55: 298–305.
  4. Patlak M (2001). "Bone builders: the discoveries behind preventing and treating osteoporosis". FASEB J. 15 (10): 1677E–E. PMID 11481214.
  5. "The National Institutes of Health (NIH) Consensus Development Program: Osteoporosis".
  6. Pagliari D, Ciro Tamburrelli F, Zirio G, Newton EE, Cianci R (2015). "The role of "bone immunological niche" for a new pathogenetic paradigm of osteoporosis". Anal Cell Pathol (Amst). 2015: 434389. doi:10.1155/2015/434389. PMC 4605147. PMID 26491648.
  7. "Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group". World Health Organ Tech Rep Ser. 843: 1–129. 1994. PMID 7941614.
  8. Macor, John (2008). Annual reports in medicinal chemistry. London, UK: Elsevier/Academic Press. ISBN 9780123743442.

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