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Common causes [1]

Less common causes of peptic ulcer disease

Rare causes of peptic ulcer disease [1]


Genetic causes -[3]

  • Peptic ulcer disease is caused by gastrinomas (Zollinger-Ellison syndrome)caused by a mutation in MEN gene present on chromosome 11q13.

Causes by organ system

  • To obtain the coding for the table seen below, click here. You need to copy the table content from the edit box, and paste it into the edit box.
  • You can then list the causes by organ system. List the causes, separated by a comma under the appropriate category where it says "No underlying causes". Erase "No underlying causes" if you are listing causes in that category.
  • For an example of the causes by organ system table in a causes microchapter, click here.
Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic Rosacea,Chronic idiopathic urticaria ,Psoriasis vulgaris ,Behcet's disease ,Alopecia areata,Sweet's syndrome [4]
Drug Side Effect serotonin reuptake -NSAIDs,Clopidogrel,spironolactone,sirolimus,bisphosphonates (when combined with NSAIDs),mycophenolate mofetil,spironolactone ,chemotherapy (hepatic infusion of 5 - fluorouracil ,selective serotonin reuptake inhibitor
Ear Nose Throat No underlying causes
Endocrine Diabetes mellitus
Environmental smoking, excess alcohol consumption, caffeine ,more common in patients with Diabetes Mellitus ,hypertension ,metabolic syndrome[5]
Gastroenterologic Crohn’s disease of the stomach or duodenum, Eosinophilic gastroduodenitis
Genetic Zollinger -Ellison syndrome associated with MEN TYPE 1 syndrome caused by mutation in MEN gene present on chromosome 11q 13
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease Helicobacter pylori (60% gastric and 50-75% duodenal ulcers ), Herpes simplex virus type 1, Cytomegalovirus, Helicobacter heilmannii, Tuberculosis, syphilis, and mucormycosis
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic Non-beta cell tumor , carcinoid syndrome , gastrinomas
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric severe stress, depressed mood, suicidal ideation and psychological counseling [5]
Pulmonary COPD,Sarcoidosis
Renal/Electrolyte Hypercalcemia
Rheumatology/Immunology/Allergy Fibromyalgia[6]
Sexual No underlying causes
Trauma Cushing ulcers
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in alphabetical order[edit | edit source] List the causes of the disease in alphabetical order.

Cause 1 Alopecia areata Cause 2 Behcet's disease Cause 3 caffeine Cause 4 Cause 5 Cause 6 Cause 7 Cause 8 Cause 9 Cause 10

  1. 1.0 1.1 Malfertheiner P, Chan FK, McColl KE (2009). "Peptic ulcer disease". Lancet. 374 (9699): 1449–61. doi:10.1016/S0140-6736(09)60938-7. PMID 19683340.
  2. Hirschowitz BI, Lanas A (2002). "Atypical and aggressive upper gastrointestinal ulceration associated with aspirin abuse". J. Clin. Gastroenterol. 34 (5): 523–8. PMID 11960062.
  3. Jensen RT, Niederle B, Mitry E, Ramage JK, Steinmuller T, Lewington V; et al. (2006). "Gastrinoma (duodenal and pancreatic)". Neuroendocrinology. 84 (3): 173–82. doi:10.1159/000098009. PMID 17312377.
  4. Kutlubay Z, Zara T, Engin B, Serdaroğlu S, Tüzün Y, Yilmaz E; et al. (2014). "Helicobacter pylori infection and skin disorders". Hong Kong Med J. 20 (4): 317–24. doi:10.12809/hkmj134174. PMID 25045884.
  5. 5.0 5.1 Lee YB, Yu J, Choi HH, Jeon BS, Kim HK, Kim SW; et al. (2017). "The association between peptic ulcer diseases and mental health problems: A population-based study: a STROBE compliant article". Medicine (Baltimore). 96 (34): e7828. doi:10.1097/MD.0000000000007828. PMC 5572011. PMID 28834889.
  6. Wang KA, Wang JC, Lin CL, Tseng CH (2017) Association between fibromyalgia syndrome and peptic ulcer disease development. PLoS One 12 (4):e0175370. DOI:10.1371/journal.pone.0175370 PMID: 28384332