Autoimmune polyendocrine syndrome historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Historical Perspective

The history associated with autoimmune polyendocrine syndrome is as below:[1][2]

  • In 19th century physicians first focussed their attention on constellation of symptoms associated with autoimmune polyendocrine syndrome.
  • In 1855, Thomas Addison identified patients with Addison's disease who also appeared to have coexisting pernicious anemia.
  • In 1929, Thorpe and Handley first described the case of mucocutaneous candidiasis with glandular failure in a 4.5-year-old girl.
  • In 1956, Roitt and Doniach found that patients with Hashimoto's thyroiditis had circulating autoantibodies reacting with thyroid gland.
  • In 1981, Neufeld and colleagues categorised autoimmune polyendocrine syndrome into type 1 and type 2.
  1. Khalid, Nauman; Chhabra, Lovely; Ahmad, Sarah Aftab; Umer, Affan; Spodick, David H. (2015). "Autoimmune Polyglandular Syndrome Type 2 Complicated by Acute Adrenal Crisis and Pericardial Tamponade in the Setting of Normal Thyroid Function". Methodist DeBakey Cardiovascular Journal. 11 (4): 250–252. doi:10.14797/mdcj-11-4-250. ISSN 1947-6094.
  2. Betterle C, Dal Pra C, Mantero F, Zanchetta R (2002). "Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction". Endocr. Rev. 23 (3): 327–64. doi:10.1210/edrv.23.3.0466. PMID 12050123.

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