Syphilis dark field microscopy

• Dark field microscopy may be performed in cases wherein serologic tests do not correspond with clinical findings suggestive of early syphilis.

• It may also be helpful in the evaluation of cutaneous lesions such as chancre or condylomata lata.

• Direct fluorescent antibody (DFA-TP) assay of fixed smears may be indicated if dark field microscopy is not available.

• Dark field microscopy and DFA-TP assay have a specificity rate of 85-92%

Resources

• Sexually transmitted diseases treatment guidelines, 2010

• Association of Public Health Laboratories (APHL). Laboratory Diagnostic Testing for Treponema pallidum. Expert Consultation Meeting Summary Report, January 13--15, 2009, Atlanta, GA

• CDC: Guidelines for the laboratory diagnosis of gonorrhea, chlamydia and syphilis

References

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