Hypoglycemia screening

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Screening

Screening of hypoglycemia should be obtained in these cases:

  • Whenever symptoms consistent with hypoglycemia occur.
  • Infants who are at risk for hypoglycemia:
  • First feed should occur within one hour after birth before screening.
  • Surveillance should be continued every three to six hours for the first 24 to 48 hours of life.[1]
  • Neonates with low blood glucose concentrations should be continuely monitored until concentrations can be maintained with regular feedings in a normal range: >50 mg/dL.
  • Hypoglycemia disorder should be considered If an infant is unable to maintain glucose concentrations >60 mg/dL after 48 hours of age.
  • plasma glucose concentration in an infant with a low glucose value determined by a glucose meter should be confirmed by laboratory measurement.[2]
  • Treatment should be started immediately after primary blood test and we sholudn't wait the confirmatory laboratory results due to high risk of neurological outcome.
  • Glucose concentration measured in whole blood is 15% lower than that in plasma.[3]
  • Continuous glucose monitoring using a sensor that measures interstitial glucose concentration was reported to be reliable. [4]

References

  1. Harris DL, Weston PJ, Harding JE (2012). "Incidence of neonatal hypoglycemia in babies identified as at risk". J Pediatr. 161 (5): 787–91. doi:10.1016/j.jpeds.2012.05.022. PMID 22727868.
  2. Committee on Fetus and Newborn. Adamkin DH (2011). "Postnatal glucose homeostasis in late-preterm and term infants". Pediatrics. 127 (3): 575–9. doi:10.1542/peds.2010-3851. PMID 21357346.
  3. Stanley CA, Rozance PJ, Thornton PS, De Leon DD, Harris D, Haymond MW; et al. (2015). "Re-evaluating "transitional neonatal hypoglycemia": mechanism and implications for management". J Pediatr. 166 (6): 1520–5.e1. doi:10.1016/j.jpeds.2015.02.045. PMC 4659381. PMID 25819173.
  4. Wackernagel D, Dube M, Blennow M, Tindberg Y (2016). "Continuous subcutaneous glucose monitoring is accurate in term and near-term infants at risk of hypoglycaemia". Acta Paediatr. 105 (8): 917–23. doi:10.1111/apa.13479. PMID 27203555.


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