Primary sclerosing cholangitis natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2]
Overview
Natural History
Complications
Some of the complications of primary sclerosing cholangitis include:[1]
- Osteoporosis: Patients with primary sclerosing cholangitis lose 1% of their bone mass every year.[2]
- Liver cirrhosis and end-stage liver disease (ESLD).
- Cholangiocarcinoma: the risk of cholangiocarcinoma in patients with primary sclerosing cholangitis is 400 times higher than the risk in the general population.[3]
Prognosis
References
- ↑ Lazaridis KN, LaRusso NF (2016). "Primary Sclerosing Cholangitis". N. Engl. J. Med. 375 (12): 1161–70. doi:10.1056/NEJMra1506330. PMID 27653566.
- ↑ Angulo P, Grandison GA, Fong DG, Keach JC, Lindor KD, Bjornsson E, Koch A (2011). "Bone disease in patients with primary sclerosing cholangitis". Gastroenterology. 140 (1): 180–8. doi:10.1053/j.gastro.2010.10.014. PMC 3043598. PMID 20955707.
- ↑ Boonstra K, Weersma RK, van Erpecum KJ, Rauws EA, Spanier BW, Poen AC, van Nieuwkerk KM, Drenth JP, Witteman BJ, Tuynman HA, Naber AH, Kingma PJ, van Buuren HR, van Hoek B, Vleggaar FP, van Geloven N, Beuers U, Ponsioen CY (2013). "Population-based epidemiology, malignancy risk, and outcome of primary sclerosing cholangitis". Hepatology. 58 (6): 2045–55. doi:10.1002/hep.26565. PMID 23775876.