Thrombophilia medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Asiri Ediriwickrema, M.D., M.H.S. [2]
Overview
- The treatment for thrombophilia depends on the underlying hypercoagulable state and the clinical presentation.
- Treatment should be tailored to the individual patient.
- The risks and benefits, required monitoring, and costs associated with each form of anticoagulation should be discussed with the patient prior to initiation of therapy.
- The mainstay of therapy for thrombophilia is anticoagulation with either warfarin, low molecular weight heparin, direct Xa inhibitors, or direct thrombin inhibitors.
- Response to anticoagulation can be monitored clinically, or with repeat ultrasongraphy for deep vein thrombosis or measuring D-dimer levels after treatment.
Medical Therapy
The treatment algorithms for various thrombophilias are presented below:
- Prophylactic anticoagulation should be used in the following scenarios:
- Post surgery
- Pregnancy and Postpartum