Sandbox: patho3

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Overview

Pathogenesis

  • The exact cell of origin of hairy cell leukemia is still unclear, however several studies have suggested that it arises from mature memory B cells, that are normally involved in the process of human immunoglobulins production.[1]

Genetics

  • The most common gene involved in the pathogenesis of hairy cell leukemia is BRAF V600E mutations.[2]
  • The BRAF V600E mutations is present in all patients with hairy cell leukemia (classic).
  • The BRAF V600E mutations is not present in patients with hairy cell leukemia (variant).
  • Other genes involved in the pathogenesis of hairy cell leukemia may include:[2]
  • Under expression of chromosomes 3p24, 3p21, 3q13.3-q22, 4p16, 11q23, 14q22-q24, 15q21-q22, 15q24-q25, and 17q22-q24.
  • Over expression of chromosomes 13q31 and Xq13.3-q21

Associated Conditions

Gross Pathology

Microscopic Pathology

  1. ↑ What is Hairy Cell Leukemia? Hairy Cell Leukemia Foundation (2015) https://www.hairycellleukemia.org/about-hcl/what-is-hairy-cell-leukemia/ Accessed on October, 19 2015
  2. ↑ 2.0 2.1 Hairy cell leukemia. Wikipedia (2015) https://en.wikipedia.org/wiki/Hairy_cell_leukemia#Pathophysiology Accessed on Ocotber, 19 2015
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