Gliomatosis cerebri natural history, complications, and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Natural History
If left untreated, patients with meningioma may progress to develop focal neurological deficits, altered mental status, hydrocephalus, brain herniation, and ultimately death.
Complication
Common complications of gliomatosis cerebri include:[1]
- Brain herniation
- Hydrocephalus
- Coma
- Metastasis
- Recurrence
- Side effects of radiation therapy
- Side effects of chemotherapy
Prognosis
Prognosis of gliomatosis cerebri is generally poor, and the 5-year survival rate of patients with treatment is approximately 17.7%.[2]
The median survival time of gliomatosis cerebri is 14 months.[3]
The prognosis of gliomatosis cerebri depends on the following:
- Resectibility of the tumor mass
- Age of the patient
- Age < 10 year is associated with worse prognosis
- Gender of the patient
- Males are associated with a better prognosis than females
- Location of tumor
- Infratentorial tumor is associated with shorter survival.[3]
- Size of the tumor
- Stage of the cancer
- Whether the cancer has just been diagnosed or has recurred
Complications
References
- ↑ Treatment and prognosis of gliomatosis cerebri. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/gliomatosis-cerebri
- ↑ Inoue T, Kumabe T, Kanamori M, Sonoda Y, Watanabe M, Tominaga T (2010). "Prognostic factors for patients with gliomatosis cerebri: retrospective analysis of 17 consecutive cases". Neurosurg Rev. 34 (2): 197–208. doi:10.1007/s10143-010-0306-1. PMID 21301914.
- ↑ 3.0 3.1 Herrlinger U, Felsberg J, Küker W, Bornemann A, Plasswilm L, Knobbe CB; et al. (2002). "Gliomatosis cerebri: molecular pathology and clinical course". Ann Neurol. 52 (4): 390–9. doi:10.1002/ana.10297. PMID 12325066.