Multiple endocrine neoplasia type 2 causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Causes
Mutations in the RET proto-oncogene cause multiple endocrine neoplasia type 2. The protein produced by the RET proto-oncogene gene normally plays an important role in signaling cells to respond to their environment, for example by dividing or maturing. Mutations in this gene cause an overactivation of the protein's signaling function, which can lead to an overgrowth of cells and the formation of tumors characteristic of multiple endocrine neoplasia type 2.