Peutz-Jeghers syndrome natural history, complications, and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
If left untreated, patients with Peutz-Jeghers syndrome may progress to develop, rectal bleeding, anemia, and abdominal pain. Common complications of Peutz-Jeghers syndrome include colon cancer, and cachexia. Prognosis is generally good if polypectomy was performed before any dysplastic degenerations take place.
Natural History
Without polypectomy, patients with Peutz-Jeghers syndrome may develop symptoms of colon cancer, which will eventually lead to death.
Complications
Complications that can develop as a result of Peutz-Jeghers syndrome are:
Prognosis
Almost half of Peutz-Jeghers patients die from cancer by age 57 years, and the cumulative risk of developing a form of cancer associated with Peutz-Jeghers syndrome between ages 15-64 is 93%.[1]
References
- ↑ "eMedicine - Peutz-Jeghers Syndrome : Article by Andrea Duchini, MD". Retrieved 2007-07-21.