Acute myeloid leukemia laboratory tests
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Carlos A Lopez, M.D. [3]
Overview
Laboratory Findings
- Laboratory findings could include some of the following:
- Complete blood count and differential count. (An abnormal result is typically the first clue to a diagnosis of acute myeloid leukemia)
- Leukocytosis
- Thrombocytopenia
- Anemia
- Leucopenia
- Peripheral blood smear (Immature blast cells can be identified)
- Liver function tests
- Renal function tests
- Coagulation studies: Prolonged bleeding and clotting time
- Blood is examined via light microscopy as well as flow cytometry to diagnose the presence of leukemia, to differentiate acute myeloid leukemia from other types of leukemia (e.g. acute lymphoblastic leukemia), and to classify the subtype of disease.
- Blood is typically also tested for chromosomal translocations by routine cytogenetics or fluorescent in situ hybridization.
The diagnosis of acute myeloid leukemia can be challenging and should be performed by a qualified hematopathologist or hematologist. In straightforward cases, the presence of certain morphologic features such as Auer rods) can distinguish acute myeloid leukemia from other leukemias. [1]
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References
- ↑ Abeloff, Martin et al. (2004), p. 2835.