Splenic marginal zone lymphoma epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [4]

Overview

Epidemiology

Less than 1% of all lymphomas are splenic marginal zone lymphomas[1] and it is postulated that SMZL may represent a large fraction of unclasssifiable CD5- chronic lymphocytic leukemias.[2]The typical patient is over the age of 50, and gender preference has been described.[3]

References

  1. [1] Armitage JO, Weisenburger DD. "New approach to classifying non-Hodgkin's lymphomas: clinical features of the major histologic subtypes. Non-Hodgkin's Lymphoma Classification Project." J Clin Oncol. 1998 Aug;16(8):2780-95. PMID: 9704731
  2. [2] Jaffe E.S., Harris N.L., Stein H., Vardiman J.W. (eds): World Health Organization Classification of Tumors. Pathology and Genetics of Tumours of Haemopoietic and Lymphoid Tissues. IARC Press: Lyon 2001
  3. [3] Berger F, Felman P, Thieblemont C, Pradier T, Baseggio L, Bryon PA, Salles G, Callet-Bauchu E, Coiffier B. "Non-MALT marginal zone B-cell lymphomas: a description of clinical presentation and outcome in 124 patients." Blood. 2000 Mar 15;95(6):1950-6. PMID: 10706860

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