Phthalylsulfathiazole

Phthalylsulfathiazole

Clinical data
ATC code	A07AB02 (WHO)
Identifiers
IUPAC name 2-[ [4-(1,3-thiazol-2-ylsulfamoyl)phenyl]carbamoyl]benzoic acid
PubChem CID	4806
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C17H13N3O5S2
Molar mass	403.43222 g/mol

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Phthalylsulfathiazole belongs to the group of drugs called sulfonamides. The drug is a broad spectrum antimicrobial that can treat different types of infections including intestinal. The mechanism of action depends is based on competitive antagonism with para-aminobenzoic acid and inhibition of dihydropteroate synthetase activity, that in turn leads to impaired synthesis of dihydrofolic acid and as a result its active metabolite that is necessary for the synthesis of purine and pyrimidine.

The drug is indicated in treatment of dysentery, colitis, gastroenteritis and intestinal surgery. Adverse effects may include allergic reactions, vitamin B insufficiency, agranulocytosis and aplastic anemia.

References

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