Fasciolosis medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Medical therapy
Anthelmintics
For high efficacy and safety, triclabendazole (Egaten®) in dose 10-12 mg/kg is drug of choice in human fasciolosis.[1] No drug alternatives are available for humans. On the other hand, nitazoxanide were successfully used in human fasciolosis treatment in Mexico.[2] Bithionol is another drug of choice used for treatment of fasciola hepatica.[3]
Antimicrobial Regimen
- Fasciola hepatica
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- Preferred regimen: Triclabendazole 10 mg/kg PO one dose[4]
- Note: Two-dose (double-dose) triclabendazole therapy can be given to patients who have severe or heavy Fasciola infections (many parasites) or who did not respond to single-dose therapy.
- Alternative regimen: Nitazoxanide 500mg PO bid for 7 days
References
- ↑ Savioli, L., Chistulo, L., Montresor, A., 1999. New opportunities for the control of fascioliasis. Bull. WHO 77, 300.
- ↑ Rossignol, J.F., Abaza, H., Friedman, H., 1998. Successful treatment of human fascioliasis with nitazoxanide. Trans. Roy. Soc. Trop. Med. Hyg. 92, 103–104.
- ↑ Ramachandran, A., 2000. Pharmacology Recall.
- ↑ "Parasites - Fascioliasis".