WBR0248
| Author | [[PageAuthor::Rim Halaby, M.D. [1] (Reviewed by Yazan Daaboul, M.D.)]] |
|---|---|
| Exam Type | ExamType::USMLE Step 1 |
| Main Category | MainCategory::Pathology |
| Sub Category | SubCategory::Hematology |
| Prompt | [[Prompt::A 6-year-old Nigerian boy is brought to the physician's office for an unexplained fever of two weeks duration. The mother explains that her child has experienced recent weight loss and night sweats that are associated with excessive fatigue, malaise, and anorexia. The family has recently immigrated from Nigeria, and the patient has not received previous medical care. The patient’s temperature is 39 °C (102.2 °F), blood pressure is 110/85 mmHg, and heart rate is 98/min. Physical examination is remarkable for severe orofacial and teeth disruption (shown below). The child’s condition is caused by a dysregulation of which gene?
|
| Answer A | AnswerA::''L-MYC'' |
| Answer A Explanation | AnswerAExp::The ''L-MYC'' oncogene is associated with lung cancers. |
| Answer B | AnswerB::''RET'' |
| Answer B Explanation | [[AnswerBExp::The RET oncogene is associated with multiple endocrine neoplasia (MEN) syndromes type 2A and 2B.]] |
| Answer C | AnswerC::''N-MYC'' |
| Answer C Explanation | [[AnswerCExp::N-MYC oncogene is associated with neuroblastoma.]] |
| Answer D | AnswerD::''HER2'' |
| Answer D Explanation | [[AnswerDExp::HER2 oncogene is associated with breast, ovarian, and gastric cancers.]] |
| Answer E | AnswerE::''C-MYC'' |
| Answer E Explanation | [[AnswerEExp::C-MYC oncogene is associated with Burkitt's lymphoma.]] |
| Right Answer | RightAnswer::E |
| Explanation | [[Explanation:: Educational Objective: |
| Approved | Approved::Yes |
| Keyword | WBRKeyword::Burkitt's lymphoma, WBRKeyword::C-myc, WBRKeyword::Oncogene, WBRKeyword::Hematologic malignancy, WBRKeyword::Fever, WBRKeyword::Constitutional symptoms |
| Linked Question | Linked:: |
| Order in Linked Questions | LinkedOrder:: |
