Liposarcoma medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Chemotherapy, chemoradiation, immunotherapy and targeted therapy are the different types of medical therapy for liposarcoma.
Medical Therapy
Chemotherapy may be used with radiation therapy either before or after surgery to try to shrink the tumor or kill any remaining cancer cells. In general, chemotherapy effects for soft tissue sarcoma have had little impact as opposed to other cancers. If the cancer has spread to other areas of the body, chemotherapy may be used to shrink tumors and reduce the pain and discomfort they cause, but is unlikely to eradicate the disease. The use of chemotherapy to prevent the spread of soft tissue sarcomas has not been proven to be effective. Patients with soft tissue sarcomas usually receive chemotherapy intravenously (injected into a blood vessel).
- Chemotherapy
It is used to kill cancer cells by various mechanisms like damaging DNA or damaging the making of DNA. It can be used as primary, adjuant or neoadjuant therapy. It is also used to treat metastasis also. Usually 2 or more chemotherapy drugs are given in combination to treat the disease. They are given in cycles of treatment days followed by days of rest. The length of the cycles varies depending on the drug used. The cycles of chemotherapy helps the body to recover faster.
- Chemoradiation
Sometimes the targeted therapy is given along with radiation . They may be given together or at different intervals.
- Targeted therapy
It stops the growth of the molecules involved in growth of cancer cells. It blocks the growth signals. Most targettd therapy comes in pill form and some needs to be injected.
- Immunotherapy
Immune system is the body's natural defense against infection and disease. Immunotherapy increases your activity of the immune system and improves body's ability to find and destroy cancer cells. Few of the drugs used for immune therapy are listed below.[1]
| Drug | Type of drug |
|---|---|
| Bevacizumab | Targeted therapy |
| Celecoxib | Targeted therapy |
| Crizotinib | Targeted therapy |
| Dacarbazine | Chemotherapy |
| Dasatinib | Targeted therapy |
| Docetaxel | Chemotherapy |
| Doxorubicin | Chemotherapy |
| Epirubicin hydrochloride | Chemotherapy |
| Everolimus | Chemotherapy |
| Gemcitabine hydrochloride | Chemotherapy |
| Ifosfamide | Chemotherapy |
| Imatinib mesylate | Targeted therapy |
| Interferon alpha 2B | Immunotherapy |
| Mesna | Chemotherapy |
| Methotrexate | Chemotherapy |
| Nilotnib | Chemotherapy |
| Paclitaxel | Chemotherapy |
| Pazopanib | Targeted therapy |
| Regorafenib | Targeted therapy |
| Sorafenib tosylate | Targeted therapy |
| Sirolimus | Chemotherapy |
| Sulindac | Chemotherapy |
| Sunitinib malate | Targeted therapy |
| Tamoxifen citrate | Targeted therapy |
| Temozolamide | Chemotherapy |
| Toremifene citrate | Targeted therapy |
| Vinblastine citrate | Chemotherapy |
| Vinblastine tartarate | Chemotherapy |
Regimen
| Drugs | Dose |
|---|---|
| Doxurubicin | Doxurubicin 75 mg/m2; 28 day cycle |
| Pegylated liposomal doxurubicin | 40-50 mg/m2 ; 28 day cycle |
| AI regimen | Doxurubicin 25 mg/m2, Ifosfamide 3g/m2 21 day cycle |
| MAID regimen | Doxurubicin 20 mg/m2, ifosfamide 2.5g/m2, Dacarbazine 300mg/m2 21 day cycle |
| AD regimen | Doxurubicin 20 mg/m2, Dacarbazine 300mg/m2; 21 day cycle |
| Metronomic cyclophosphamide | Oral daily cyclophosphamide 50mg/day for 21 dyas on 28 day cycle |
| Docetaxel-Gemcitabine | Gemcitabine 900 mg/m2 , Docetaxel 100 mg/m2 for 21 day cycle |
| Trabectidin | Trabectidin 1.5mg/m2 21 day cycle[2] |