High triglyceride causes

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Template:Hypertriglyceridemia

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]

Overview

Causes

Genetics

Type I hyperlipoproteinemia

  • Genetic deficiency or dysfunction of enzyme lipoprotein lipase (LPL) or its cofactor, apo C-II.

Familial combined hyperlipidemia

  • Autosomal dominant disorder
  • Patients have either isolated triglyceride or LDL-c elevations or both.
  • Family history of premature coronary artery disease in 1 or more first-degree relatives
  • Family history for elevated triglycerides with or without elevated LDL-c levels.

Familial hypertriglyceridemia

  • Autosomal dominant trait
  • These patients and their families have isolated triglyceride elevations
  • Increased risk of premature coronary artery disease.

Metabolic

Drugs

  • Diuretics (high dose thiazideor chlorthalidone)
  • Beta-blockers (high doses)
  • Estrogen replacement therapy
  • Oral contraceptives (high estrogen )
  • Tamoxifen
  • Glucocorticoids
  • Oral isotretinoin
  • Antiretroviral therapy (protease inhibitors, nonnucleoside reverse transcriptase inhibitors)
  • Atypical antipsychotics

Miscellaneous

Idiopathic (constitutional)

References


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