Adrenal insufficiency epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Epidemiology and Demographics

Incidence

• The incidence of adrenal insufficiency is approximately 0.8 new cases per 100,000 individuals per year individuals in the developed world.
• The incidence of adrenal insufficiency in Europe is approximately 4.4 to 6.2 new cases per 100,000 individuals per year.

Prevalence

• The prevalence of adrenal insufficiency is approximately 4-11 cases per 100,000 individuals in the developed world.
• In 2016, Iceland reported the highest prevalence of 221 cases per 100,000 individuals.

Case-fatality rate/Mortality rate

• The mortality rate of adrenal crisis is approximately 0.5/100 patients/year.

Age

• Patients of all age groups may develop adrenal insufficiency.
• Primary adrenal insufficiency commonly affects individuals between 30 to 50 years of age.
• Secondary adrenal insufficiency commonly affects individuals in the 60s.
• The incidence of adrenal crisis increase with age greater than 60 years.

Race

• There is no racial predilection to adrenal insufficiency

Gender

• [Disease name] affects men and women equally.
• [Gender 1] are more commonly affected by [disease name] than [gender 2]. The [gender 1] to [gender 2] ratio is approximately [number > 1] to 1.

Region

• The majority of [disease name] cases are reported in [geographical region].

• [Disease name] is a common/rare disease that tends to affect [patient population 1] and [patient population 2].