Biliary dyskinesia medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shakiba Hassanzadeh, MD[2]
Overview
Medical therapy mostly includes of symptomatic treatment of abdominal pain and IV opiates are the drug of choice, although some studies have suggested that opiates cause SOD contraction.
Medical Therapy
- Medical therapy mostly includes of symptomatic treatment of abdominal pain:[1][2]
- Opiates (intravenous) are the drug of choice, although some studies have suggested that opiates cause sphincter of Oddi (SOD) contraction.
- Muscle relaxants have been reported to be ineffective.
- Calcium channel blockers (CCB) have been reported to be ineffective.
- However, CCBs like nifedipine have been reported to have potential effect in improving the pain but headache and tachycardia are the adverse effects.[3]
- Alternative treatments that may be effective by a cholagogue effect (increases bile discharge from the biliary system), or a choleretic effect (increases bile secretion from the liver) include:[4]
- Other reported effective measures in biliary dyskinesia include:[5]
- Smoking cessation
- Avoidance of fatty food
- Frequent meal consumption
- Lying on the right side after meals
- Weight loss
- Increase in physical activity
References
- ↑ Wilkins T, Agabin E, Varghese J, Talukder A (2017). "Gallbladder Dysfunction: Cholecystitis, Choledocholithiasis, Cholangitis, and Biliary Dyskinesia". Prim Care. 44 (4): 575–597. doi:10.1016/j.pop.2017.07.002. PMID 29132521.
- ↑ Behar J, Corazziari E, Guelrud M, Hogan W, Sherman S, Toouli J (2006). "Functional gallbladder and sphincter of oddi disorders". Gastroenterology. 130 (5): 1498–509. doi:10.1053/j.gastro.2005.11.063. PMID 16678563.
- ↑ Sand J, Nordback I, Koskinen M, Matikainen M, Lindholm TS (1993). "Nifedipine for suspected type II sphincter of Oddi dyskinesia". Am J Gastroenterol. 88 (4): 530–5. PMID 8470634.
- ↑ Toouli J (2002). "Biliary Dyskinesia". Curr Treat Options Gastroenterol. 5 (4): 285–291. doi:10.1007/s11938-002-0051-9. PMID 12095476.
- ↑ Bistritz L, Bain VG (2006). "Sphincter of Oddi dysfunction: managing the patient with chronic biliary pain". World J Gastroenterol. 12 (24): 3793–802. doi:10.3748/wjg.v12.i24.3793. PMC 4087924. PMID 16804961.