Olsalazine

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Olsalazine
Clinical data
Pregnancy; category	US: C (Risk not ruled out) ; ;
ATC code	A07EC03 (WHO) ;
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Protein binding	99%
Elimination half-life	0.9 hours
Identifiers
	IUPAC name 5 - [(2Z) - 2 - (3 - carboxy - 4 - oxo - 1 - cyclohexa - 2,5 - dienylidene)hydrazinyl] - 2 - hydroxy - benzoic acid;
CAS Number	15722-48-2;
PubChem CID	6003770;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C14H10N2O6
Molar mass	302.239g/mol

Overview

Olsalazine is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease and Ulcerative Colitis. It is sold under the name Dipentum.

The chemical name is 3,3' -azobis (6-hydroxybenzoate)salicylic acid. It is sold as the disodium salt.

Like Balsalazide, Olsalazine is believed to deliver Mesalazine, or 5-aminosalicylic acid (5-ASA), past the small intestine, directly to the large intestine, which is that active site of disease in ulcerative colitis.

History

Olsalazine gained Food and Drug Administration (FDA) approval in 1990.

Supply

The drug is supplied by UCB Pharma.

Other indications

The Australian biotech company Giaconda has developed a combination therapy for treat constipation-predominant Irritable Bowel Syndrome that uses olsalazine and the anti-gout drug colchicine.

External links

Template:Antidiarrheals, intestinal anti-inflammatory/anti-infective agents

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