Cryptogenic stroke

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In neurology, Cryptogenic stroke is stroke of undetermined source.

One cause is paradoxical embolism that may be treated with patent foramen ovale closure[1][2].

One cause is Atrial fibrillation[3][4].

For cryptogenic stroke on unknown source, anticoagulation may not help over aspirin[5].

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References

  1. Mas JL, Derumeaux G, Guillon B, Massardier E, Hosseini H, Mechtouff L; et al. (2017). "Patent Foramen Ovale Closure or Anticoagulation vs. Antiplatelets after Stroke". N Engl J Med. 377 (11): 1011–1021. doi:10.1056/NEJMoa1705915. PMID 28902593. Review in: Ann Intern Med. 2018 Jan 16;168(2):JC7
  2. Saver JL, Carroll JD, Thaler DE, Smalling RW, MacDonald LA, Marks DS; et al. (2017). "Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke". N Engl J Med. 377 (11): 1022–1032. doi:10.1056/NEJMoa1610057. PMID 28902590.
  3. Sanna T, Diener HC, Passman RS, Di Lazzaro V, Bernstein RA, Morillo CA; et al. (2014). "Cryptogenic stroke and underlying atrial fibrillation". N Engl J Med. 370 (26): 2478–86. doi:10.1056/NEJMoa1313600. PMID 24963567.
  4. Edwards SJ, Wakefield V, Jhita T, Kew K, Cain P, Marceniuk G (2020). "Implantable cardiac monitors to detect atrial fibrillation after cryptogenic stroke: a systematic review and economic evaluation". Health Technol Assess. 24 (5): 1–184. doi:10.3310/hta24050. PMC 6983910 Check |pmc= value (help). PMID 31944175.
  5. Diener HC, Sacco RL, Easton JD, Granger CB, Bernstein RA, Uchiyama S; et al. (2019). "Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source". N Engl J Med. 380 (20): 1906–1917. doi:10.1056/NEJMoa1813959. PMID 31091372.