Thrombocytopenia pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor-In-Chief: Farbod Zahedi Tajrishi
Overview
Pathophysiology
Physiology
Platelets are produced in hematopoiesis by budding off from megakaryocytes, which are derived from multipotent hematopoietic progenitor cells.[1] Each megakaryocyte produces 1000 to 5000 platelets. Platelets circulate for approximately one week, and are then destroyed by the spleen and by Kuppfer cells in the liver.
Pathogenesis
It is thought that thrombocytopenia is the result of either of these mechanisms:
- decreased production of platelets in the bone marrow,
- destruction of platelets outside of bone marrow,
- blood dilution from fluid resuscitation or massive transfusion,
- sequestration of platelets in the spleen due to portal hypertension and/or splenomegaly.
References
- ↑ Klein LS, Shih HT, Hackett FK, Zipes DP, Miles WM (1992). "Radiofrequency catheter ablation of ventricular tachycardia in patients without structural heart disease". Circulation. 85 (5): 1666–74. PMID 1572025.