TRIM68

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Tripartite motif-containing protein 68 is a protein that in humans is encoded by the TRIM68 gene.[1][2]

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted to prostate. This gene was also found to be differentially expressed in androgen-dependent versus androgen-independent prostate cancer cells.[2]

Interactions

TRIM68 has been shown to interact with Androgen receptor.[3]

References

  1. Chang GT, Steenbeek M, Schippers E, Blok LJ, van Weerden WM, van Alewijk DC, Eussen BH, van Steenbrugge GJ, Brinkmann AO (Oct 2001). "A novel gene on human chromosome 2p24 is differentially expressed between androgen-dependent and androgen-independent prostate cancer cells". Eur J Cancer. 37 (16): 2129–34. doi:10.1016/S0959-8049(01)00259-3. PMID 11597395.
  2. 2.0 2.1 "Entrez Gene: TRIM68 tripartite motif-containing 68".
  3. Miyajima, Naoto; Maruyama Satoru; Bohgaki Miyuki; Kano Satoshi; Shigemura Masahiko; Shinohara Nobuo; Nonomura Katsuya; Hatakeyama Shigetsugu (May 2008). "TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells". Cancer Res. United States. 68 (9): 3486–94. doi:10.1158/0008-5472.CAN-07-6059. PMID 18451177.

Further reading