Sandbox ID Skin and Soft Tissues
- Animal bite
- Preferred regimen (1): Amoxicillin-clavulanate 875/125 mg PO bid (Some gram-negative rods are resistant; misses MRSA)
- Preferred regimen (2): Ampicillin-sulbactam 1.5–3.0 g IV every 6–8 h (Some gram-negative rods are resistant; misses MRSA)
- Preferred regimen (3): Piperacillin-tazobactam 3.37 g IV every 6–8 h (Misses MRSA)
- Preferred regimen (4): Doxycycline 100 mg PO bid OR 100 mg IV every 12 h (Excellent activity against Pasteurella multocida; some streptococci are resistant)
- Preferred regimen (5): Penicillin AND dicloxacillin 500 mg oral
- Preferred regimen (6): sulfamethoxazole-trimethoprim 160–800 mg PO bid OR IV 5–10 mg/kg/day of TMP component (Good activity against aerobes; poor activity against anaerobes)
- Preferred regimen (7): Metronidazole250–500 mg PO tid OR 500 mg IV every 8 h (Good activity against anaerobes; no activity against aerobes)
- Preferred regimen (8): Clindamycin300 mg PO tid OR 600 mg IV every 6–8 h (Good activity against staphylococci, streptococci, and anaerobes; misses P. multocida)
- Preferred regimen (9): Cefuroxime 500 mg PO bid OR 1 g IV every 12 h
- Preferred regimen (10): Cefoxitin 1g IV every 6–8 h
- Preferred regimen (11): Ceftriaxone 1g IV every 12 h
- Preferred regimen (12): Cefotaxime 1–2 g IV every 6–8 h
- Preferred regimen (13): Ciprofloxacin 500–750 mg PO bid OR 400 mg IV every 12 h
- Preferred regimen (14): Levofloxacin 750 mg PO daily OR 750 mg IV daily
- Preferred regimen (15): Moxifloxacin 400 mg PO daily OR 400 mg IV daily (Monotherapy; good for anaerobes also)
- Human bite
- Preferred regimen (15): Amoxicillin-clavulanate 875/125 mg PO bid (Some gram-negative rods are resistant; misses MRSA)
- Preferred regimen (15): Ampicillin-sulbactam 1.5–3.0 g IV every 6 h (Some gram-negative rods are resistant; misses MRSA)
- Preferred regimen (15): Doxycycline PO 100 mg bid (Good activity against Eikenella species, staphylococci, and anaerobes; some streptococci are resistant)
- Preferred regimen (1): (Penicillin Voral 500 mg 4 times daily (qid) for 7–10 days
- Preferred regimen (2): (Ciprofloxacin 500 mg by mouth (po) bid OR levofloxacin 500 mg intravenously (IV)/po every 24 hours × 60 days is recommended for bioterrorism cases because of presumed aerosol exposure
- Preferred regimen (1): (azithromycin
- Patients >45 kg: 500 mg on day 1 followed by 250 mg for 4 additional days
- Patients <45 kg: 10 mg/kg on day 1 and 5 mg/kg for 4 more days
- Preferred regimen (2): (erythromycin 500 mg by mouth (po) qid OR doxycycline 100 mg bid orally for 2 weeks to 2 months
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- Preferred regimen: (Penicillin (500 mg qid) OR amoxicillin (500 mg 3 times daily [tid]) for 7–10 days
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- Preferred regimen: (Ceftazidime, gentamicin, imipenem, doxycycline, or ciprofloxacin is recommended based on in vitro susceptibility
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- Preferred regimen: (streptomycin (15 mg/kg intramuscularly [IM] every 12 hours) OR doxycycline (100 mg bid po) OR gentamicin could be substituted for streptomycin
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- Preferred regimen (1): (streptomycin (15 mg/kg every 12 hours IM) OR gentamicin (1.5 mg/kg every 8 hours IV)
- Preferred regimen (2): (tetracycline (500 mg qid) OR doxycycline (100 mg bid po) is recommended for treatment of mild cases of tularemia
- Mastitis
- Breast Implant
- Non-puerpural mastitis
- Postpartum mastitis
- Abscess
- Boils
- Furuncles
- Furunculosis, recurrent
- Pilonidal cyst
- Paronychia
- Acne
- Rosacea
- Acne vulgaris
- Cutaneous anthrax
- Bacillary angiomatosis
- Bullous or vesicular lesions
- Bullous impetigo
- Chickenpox
- Hemorrhagic
- Herpes simplex
- Herpes zoster
- Shingles
- Staphylococcal scalded skin syndrome
- Varicella
- Vibro species
- Cellulitis
- Cellulitis in diabetic patients
- Erysipelas
- Facial cellulitis
- Cellulitis in non-diabetic patients
- Orbital cellulitis
- Cellulitis caused by Vibro species
- Burns
- Non-infected wound
- Infected wound
- Erythema nodosum
- Superficial infections
- Ecthyma
- Impetigo
- Preferred regimen (1): Dicloxacillin 250 mg PO qid
- Preferred regimen (2): Cephalexin 250 mg PO qid (Pediatric dose : Cephalexin Orally 25–50 mg/kg/d in 3–4 divided doses)
- Preferred regimen (3): Erythromycin250 mg qid PO (Pediatric dose : Erythromycin 40 mg/kg/d in 3–4 divided doses PO)(Some strains of Staphylococcus aureus and Streptococcus pyogenes may be resistant).
- Preferred regimen (4): Clindamycin300–400 mg qid PO (Pediatric dose : Clindamycin 20 mg/kg/d in 3 divided doses PO)
- Preferred regimen (5): Amoxicillin-clavulanate875/125 mg bid po (Pediatric dose : 25 mg/kg/d of the amoxicillin component in 2 divided doses po)
- Preferred regimen (6): Retapamulin ointment applied to lesions bid (Pediatric dose : Apply to lesions bid)(For patients with limited number of lesions)
- Preferred regimen (7): Mupirocin ointment applied to lesions bid (Pediatric dose : Apply to lesions bid)(For patients with limited number of lesions)
- Folliculitis
- Seborrheic dermatitis
- Lyme disease
- Lyme disease, Early
- Lyme disease, Post-exposure prophylaxis
- Lyme disease, Post-lyme disease syndrome
- Ecthyma contagiosum
- Erythrasma
- Vascular insufficieny ulcers
- Wound infections
- Post-operative, negative Gram-stain
- Post-operative, positive Gram-stain
- Surgery of Intestinal or Genitourinary Tract Single-drug regimens
- Preferred regimen (1): Ticarcillin-clavulanate 3.1 g every 6 h IV
Piperacillin-tazobactam 3.375 g every 6 h or 4.5 g every 8 h IV Imipenem-cilastatin 500 mg every 6 h IV Meropenem 1 g every 8 h IV Ertapenem 1 g every 24 h IV Combination regimens Ceftriaxone 1 g every 24 h + metronidazole 500 mg every 8 h IV Ciprofloxacin 400 mg IV every 12 h or 750 mg po every 12 h + metronidazole 500 mg every 8 h IV Levofloxacin 750 mg IV every 24 h + metronidazole 500 mg every 8 h IV Ampicillin-sulbactam 3 g every 6 h + gentamicin or tobramycin 5 mg/kg every 24 h IV Surgery of trunk or extremity away from axilla or perineum Oxacillin or nafcillin 2 g every 6 h IV Cefazolin 0.5–1 g every 8 h IV Cephalexin 500 mg every 6 h po SMX-TMP 160–800 mg po every 6 h Vancomycin 15 mg/kg every 12 h IV Surgery of axilla or perineuma Metronidazole 500 mg every 8 h IV plus Ciprofloxacin 400 mg IV every 12 h or 750 mg po every 12 h IV po Levofloxacin 750 mg every 24 h IV po Ceftriaxone 1 g every 24 h
- Post-trauma
- Yaws