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==Overview==
==Overview==
The causative agent Japanese encephalitis virus is an enveloped virus of the genus flavivirus; it is closely related to the [[West Nile virus]] and [[St. Louis encephalitis]] virus. Positive sense single stranded RNA genome is packaged in the capsid, formed by the capsid protein. The outer envelope is formed by envelope (E) protein and is the protective antigen. It aids in entry of the virus to the inside of the cell. The genome also encodes several nonstructural proteins also (NS1,NS2a,NS2b,NS3,N4a,NS4b,NS5). NS1 is produced as secretory form also. NS3 is a putative helicase, and NS5 is the viral polymerase. It has been noted that the Japanese encephalitis virus (JEV) infects the [[lumen]] of the [[endoplasmic reticulum]] (ER) and rapidly accumulates substantial amounts of viral proteins for the JEV.     
The causative agent, Japanese encephalitis virus is an [[enveloped virus]] of the [[genus]] [[flavivirus]]; it is closely related to the [[West Nile virus]] and [[St. Louis encephalitis]] virus. [[Positive-sense ssRNA virus|Positive-sense single stranded RNA]] [[genome]] is packaged in the [[capsid]], formed by the capsid protein. The outer [[envelope (biology)|envelope]] is formed by envelope (E) protein and is the protective [[antigen]]. It aids in entry of the virus to the inside of the cell. The genome also encodes several nonstructural proteins also (NS1,NS2a,NS2b,NS3,N4a,NS4b,NS5). NS1 is produced as secretory form also. NS3 is a putative [[helicase]], and NS5 is the viral [[polymerase]]. It has been noted that the Japanese encephalitis virus (JEV) infects the [[lumen]] of the [[endoplasmic reticulum]] (ER) and rapidly accumulates substantial amounts of viral proteins for the JEV.     


==References==
==References==

Revision as of 20:09, 27 December 2012

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

The causative agent, Japanese encephalitis virus is an enveloped virus of the genus flavivirus; it is closely related to the West Nile virus and St. Louis encephalitis virus. Positive-sense single stranded RNA genome is packaged in the capsid, formed by the capsid protein. The outer envelope is formed by envelope (E) protein and is the protective antigen. It aids in entry of the virus to the inside of the cell. The genome also encodes several nonstructural proteins also (NS1,NS2a,NS2b,NS3,N4a,NS4b,NS5). NS1 is produced as secretory form also. NS3 is a putative helicase, and NS5 is the viral polymerase. It has been noted that the Japanese encephalitis virus (JEV) infects the lumen of the endoplasmic reticulum (ER) and rapidly accumulates substantial amounts of viral proteins for the JEV.

References


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