Cardiac disease in pregnancy and drug therapy: Difference between revisions
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*[[Atenolol]] | *[[Atenolol]] | ||
*[[Carvedilol]] | *[[Carvedilol]] | ||
* Thrombolytics efficacy and safety is mostly untested | |||
:*Greatest experience in massive [[pulmonary embolism]] | |||
:*[[Streptokinase]] does not cross placental membrane in animals, but Ab found in neonatal spinal cord fluid | |||
:*[[Urokinase]] not teratogenic in mice/rats | |||
:*Risk for maternal hemorrhage (1 case of placental abruption reported); increased risk when given at time of delivery | |||
:*Delivery best delayed at least 2-3 weeks | |||
==Acceptable Drugs== | ==Acceptable Drugs== |
Revision as of 00:59, 11 October 2012
Cardiac disease in pregnancy Microchapters |
Diagnosis |
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Catheterization: |
Treatment |
Special Scenarios:
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Cardiac disease in pregnancy and drug therapy On the Web |
American Roentgen Ray Society Images of Cardiac disease in pregnancy and drug therapy |
Directions to Hospitals Treating Cardiac disease in pregnancy |
Risk calculators and risk factors for Cardiac disease in pregnancy and drug therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
ACE inhibtors, Angiotensin receptor blockers (ARBss), and warfarin should be avoided in pregnancy.
Contraindicated Drugs
Drugs to be Avoided
- Atenolol
- Carvedilol
- Thrombolytics efficacy and safety is mostly untested
- Greatest experience in massive pulmonary embolism
- Streptokinase does not cross placental membrane in animals, but Ab found in neonatal spinal cord fluid
- Urokinase not teratogenic in mice/rats
- Risk for maternal hemorrhage (1 case of placental abruption reported); increased risk when given at time of delivery
- Delivery best delayed at least 2-3 weeks
Acceptable Drugs
- ASA - low dose
- Nitrates – use low dose to prevent fetal distress
- Beta-1 selective Beta-blockers like lopressor, metoprolol.
- Magnesium
- Morphine sulfate