Cardiac disease in pregnancy and drug therapy: Difference between revisions
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{{Cardiac disease in pregnancy}} | |||
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==Overview== | |||
[[ACE inhibtors]], [[Angiotensin receptor blockers]] ([[ARBs]]s), and warfarin should be avoided in pregnancy. | |||
==Contraindicated Drugs== | ==Contraindicated Drugs== |
Revision as of 00:51, 11 October 2012
Cardiac disease in pregnancy Microchapters |
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Cardiac disease in pregnancy and drug therapy On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
ACE inhibtors, Angiotensin receptor blockers (ARBss), and warfarin should be avoided in pregnancy.
Contraindicated Drugs
Drugs to be Avoided
Acceptable Drugs
- ASA - low dose
- Nitrates – use low dose to prevent fetal distress
- Beta-1 selective Beta-blockers like lopressor, metoprolol.
- Magnesium
- Morphine sulfate
- Avoid ACE inhibitors and warfarin due to teratogenicity
- Thrombolytics mostly untested
· Greatest experience in massive pulmonary embolism
· Streptokinase does not cross placental membrane in animals, but Ab found in neonatal spinal cord fluid
· Urokinase not teratogenic in mice/rats
· Risk for maternal hemorrhage (1 case of placental abruption reported); increased risk when given at time of delivery
· Delivery best delayed at least 2-3 weeks