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'''Historical perspective:''' | |||
Primary intestinal lymphangiectasia (Waldmann<nowiki>'s disease) was first discovered by Waldmann T.A. in 1961 when he reported 18 cases of patients having edema with low serum albumin and gammaglobulin and proteins levels ''</nowiki>idiopathic hypercatabolic hypoproteinemia"<ref name="pmid13782654">{{cite journal| author=WALDMANN TA, STEINFELD JL, DUTCHER TF, DAVIDSON JD, GORDON RS| title=The role of the gastrointestinal system in "idiopathic hypoproteinemia". | journal=Gastroenterology | year= 1961 | volume= 41 | issue= | pages= 197-207 | pmid=13782654 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=13782654 }}</ref>. Assessment using radio-labeled <sup>131</sup>I-albumin resulted in low levels in those patients. In addition, small intestinal biopsies were examined under microscope revealing different degrees of lymphatic vessel dilatation<ref name="pmid18294365">{{cite journal| author=Vignes S, Bellanger J| title=Primary intestinal lymphangiectasia (Waldmann's disease). | journal=Orphanet J Rare Dis | year= 2008 | volume= 3 | issue= | pages= 5 | pmid=18294365 | doi=10.1186/1750-1172-3-5 | pmc=2288596 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18294365 }}</ref>. | |||
Revision as of 04:42, 16 January 2021
Historical perspective:
Primary intestinal lymphangiectasia (Waldmann's disease) was first discovered by Waldmann T.A. in 1961 when he reported 18 cases of patients having edema with low serum albumin and gammaglobulin and proteins levels ''idiopathic hypercatabolic hypoproteinemia"[1]. Assessment using radio-labeled 131I-albumin resulted in low levels in those patients. In addition, small intestinal biopsies were examined under microscope revealing different degrees of lymphatic vessel dilatation[2].
References
- ↑ WALDMANN TA, STEINFELD JL, DUTCHER TF, DAVIDSON JD, GORDON RS (1961). "The role of the gastrointestinal system in "idiopathic hypoproteinemia"". Gastroenterology. 41: 197–207. PMID 13782654.
- ↑ Vignes S, Bellanger J (2008). "Primary intestinal lymphangiectasia (Waldmann's disease)". Orphanet J Rare Dis. 3: 5. doi:10.1186/1750-1172-3-5. PMC 2288596. PMID 18294365.