Sandbox:Marufa Marium: Difference between revisions

Jump to navigation Jump to search
No edit summary
No edit summary
Line 4: Line 4:
Von Willebrand’s Disease:
Von Willebrand’s Disease:
==Historical Perspective==
==Historical Perspective==
Von Willebrand’s Disease(vWD) was first discovered by Erik Adolf von Willebrand, a Finnish Physician, in 1926, in a Swedish-language article “Hereditär pseudohemofili” ("Hereditary pseudohemophilia") after assessing a 5 year-old Finnish Girl and 66 members of her family from 1924-1926. In 1957, decreased level of a plasma factor ‘ Factor ⅷ later called ‘Von Willebrand factor’ were first identified in the pathogenesis of Von Willebrand’s Disease. In early 1970s Ristocetin was used to diagnose vWD after inducing platelet aggregation <ref name="pmid24978322">{{cite journal |vauthors=Favaloro EJ |title=Diagnosing von Willebrand disease: a short history of laboratory milestones and innovations, plus current status, challenges, and solutions |journal=Semin. Thromb. Hemost. |volume=40 |issue=5 |pages=551–70 |date=July 2014 |pmid=24978322 |doi=10.1055/s-0034-1383546 |url=}}</ref> . Later immunoprecipitation techniques were used to understand vWD and it’s varieties. [[https://www.wikidoc.org/index.php/File:Platelets.jpg|thumb|300px|left|]]
Von Willebrand’s Disease(vWD) was first discovered by Erik Adolf von Willebrand, a Finnish Physician, in 1926, in a Swedish-language article “Hereditär pseudohemofili” ("Hereditary pseudohemophilia") after assessing a 5 year-old Finnish Girl and 66 members of her family from 1924-1926. In 1957, decreased level of a plasma factor ‘ Factor ⅷ later called ‘Von Willebrand factor’ were first identified in the pathogenesis of Von Willebrand’s Disease. In early 1970s Ristocetin was used to diagnose vWD after inducing platelet aggregation <ref name="pmid24978322">{{cite journal |vauthors=Favaloro EJ |title=Diagnosing von Willebrand disease: a short history of laboratory milestones and innovations, plus current status, challenges, and solutions |journal=Semin. Thromb. Hemost. |volume=40 |issue=5 |pages=551–70 |date=July 2014 |pmid=24978322 |doi=10.1055/s-0034-1383546 |url=}}</ref> . Later immunoprecipitation techniques were used to understand vWD and it’s varieties. [[File:Platelets.jpg|thumb|300px|left|]]
==Classification==
==Classification==
[[vWD]] may be classified according to [[Hereditary]] and [[Aquired]] causes.  
[[vWD]] may be classified according to [[Hereditary]] and [[Aquired]] causes.  

Revision as of 23:54, 8 September 2020


Overview

Von Willebrand’s Disease:

Historical Perspective

Von Willebrand’s Disease(vWD) was first discovered by Erik Adolf von Willebrand, a Finnish Physician, in 1926, in a Swedish-language article “Hereditär pseudohemofili” ("Hereditary pseudohemophilia") after assessing a 5 year-old Finnish Girl and 66 members of her family from 1924-1926. In 1957, decreased level of a plasma factor ‘ Factor ⅷ later called ‘Von Willebrand factor’ were first identified in the pathogenesis of Von Willebrand’s Disease. In early 1970s Ristocetin was used to diagnose vWD after inducing platelet aggregation [1] . Later immunoprecipitation techniques were used to understand vWD and it’s varieties.

Classification

vWD may be classified according to Hereditary and Aquired causes. vWD is sub-classified according to Hereditary in four types.

  • Type 1
  • Type 2: Type 2 is further divided into 4 subtypes: 2A, 2B, 2M, 2N
  • Type 3
  • Pseudo or platelet-type

Aquired vWD is thought to be caused by Autoantibodies. It can be subclassified into lymphoproliferative, cardiovascular, myeloproliferative, neoplastic, autoimmune disorders [2].

Another classification has been made by The International Society On Thrombosis And Hemostasis on the basis of Qualitative and Quantitative defects of vWF [3].



References

  1. Favaloro EJ (July 2014). "Diagnosing von Willebrand disease: a short history of laboratory milestones and innovations, plus current status, challenges, and solutions". Semin. Thromb. Hemost. 40 (5): 551–70. doi:10.1055/s-0034-1383546. PMID 24978322.
  2. Kumar S, Pruthi RK, Nichols WL (February 2002). "Acquired von Willebrand disease". Mayo Clin. Proc. 77 (2): 181–7. doi:10.4065/77.2.181. PMID 11838652.
  3. Sadler, J Evan (2018). "A Revised Classification of von Willebrand Disease". Thrombosis and Haemostasis. 71 (04): 520–525. doi:10.1055/s-0038-1642471. ISSN 0340-6245.